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Priscilla Chan and Mark Zuckerberg: Frontier AI + Virtual Biology To Solve All Diseases

Overview

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Priscilla Chan and Mark Zuckerberg: Frontier AI + Virtual Biology To Solve All Diseases

Latent Space: The AI Engineer Podcast

Nov 06
Latent Space: The AI Engineer Podcast

Latent Space: The AI Engineer Podcast

Nov 06
OverviewShownoteHighlightsTranscriptChaptersPins

Shownote

Today’s guests are Priscilla Chan and Mark Zuckerberg, co-founders of Biohub (fka Chan Zuckerberg Initiative). They are one of the leading institutes for AI x Bio and open science research with projects like CELLxGENE, rbio1, VariantFormer, and many more. ...

Highlights

In this conversation, Priscilla Chan and Mark Zuckerberg reflect on a decade of scientific innovation through the Chan Zuckerberg Initiative, now advancing one of the most ambitious frontiers in modern science: merging artificial intelligence with biology to reimagine how we understand and treat disease.
09:28
AI is the next step in software 'eating the world', now transforming biology.
10:45
Hierarchical modeling starts with proteins, then cells, leading to a virtual immune system.
13:58
The billion-cell project is much faster and cheaper than previous efforts
21:20
A recent diffusion model can generate synthetic cells for biological research.
26:33
AI models will first help generate hypotheses before replacing wet labs
28:47
Alex Reeves will lead the Evolutionary Scale program, combining AI and biology to advance frontier protein models.
30:15
AI models could predict how genetic variants affect cells and disease pathways.
45:21
CAR T cells exemplify how engineered immune cells can target cancer, paving the way for broader applications in disease prevention.
51:44
Curing diseases requires collaborative AI-biology networks

Chapters

Introduction and CZI's 10-Year Anniversary
00:00
Learning from Bill Gates
00:56
Science vs Translation
04:05
The Power of Physical Proximity in Science
10:45
Building the Virtual Cell: From Data to Models
13:55
Microscopes, Imaging, and Converting Atoms to Bits
15:51
AI Meets Biology: The Frontier Lab Concept
23:18
How Models Can Enable More Ambitious Research
27:25
Joining Forces with Evolutionary Scale
28:45
Precision Medicine and Clinical Impact
30:15
The Virtual Immune System and Cellular Engineering
45:17
Accelerating the Timeline: What It Takes to Cure All Disease
48:27

Transcript

Alessio: Hey everyone, welcome to the Latent Space podcast. This is Alessio, founder of Kernel Labs, and I'm joined by swyx, editor of Latent Space. Hello, we're so delighted to be in the Imaging Institute of Biohub with literally C and Z. Welcome Mark and...