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Improve Energy & Longevity by Optimizing Mitochondria | Dr. Martin Picard

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Improve Energy & Longevity by Optimizing Mitochondria | Dr. Martin Picard

Huberman Lab

3 DAYS AGO
Huberman Lab

Huberman Lab

3 DAYS AGO
OverviewShownoteHighlightsTranscriptChaptersPins

Shownote

Dr. Martin Picard, PhD, is a professor of behavioral medicine at Columbia University and an expert on how our behaviors and psychology shape cellular energy production and rates of aging. He explains that your mitochondria don’t just “make energy”; they tr...

Highlights

This conversation delves into the profound connection between our daily experiences and the microscopic engines within our cells—mitochondria—revealing how these tiny organelles do far more than produce energy.
02:52
Gray hair due to stress is reversible.
03:52
Energy is the potential for change.
10:40
We don't experience energy directly, only its changes.
23:35
Mitochondria pattern raw energy into biological information like a Morse code system
25:27
All mitochondria in the body are genetically identical and inherited solely from the mother.
33:59
Mitochondria function as social organisms with division of labor, fusing into filaments and adapting to cellular needs.
36:52
We are fundamentally the flow of energy through our bodies
46:06
Pregnancy may represent the upper limit of sustained human energy expenditure.
49:28
Sickness behavior like lethargy and loss of appetite helps conserve energy for the immune system
55:14
We feel the transformation of neural energy rather than energy quantity.
59:38
It's the flow of energy, not just the physical body, that tries to survive.
1:05:19
Sense of purpose correlates with mitochondrial function in the brain
1:13:14
Biomedicine's exclusion of the mind limits true understanding of health and fulfillment
1:18:26
Inflammation is an energetic state triggered by mitochondrial dysfunction and hypoxia
1:27:03
Faster puberty may predict quicker aging and shorter lifespan
1:34:07
Stimulants like cocaine borrow energy from the future, increasing risk of heart failure
1:39:31
Blocking GDF-15 doubled mortality in chemotherapy patients despite targeting weight loss.
1:44:59
Only 7% of longevity is gene-dictated; lifestyle determines the rest.
1:55:37
Three mitochondrial proteins are consistently upregulated in gray hair compared to dark hair.
2:03:36
Meditation can reduce energy expenditure by up to 40% in trained individuals, more than sleep
2:08:08
Stress hormones increase the energetic cost of life in cells.
2:17:18
Ketogenic diet brought mental clarity but was hard to maintain due to dietary restrictions
2:20:14
Alcohol forces the body to prioritize detoxification over repair, wasting valuable energy.
2:30:39
Frustration indicates the brain is ready to change
2:40:38
Methylene blue may intercalate into DNA and cause mutations, posing risks for healthy individuals.
2:47:31
Too much 'doing' without 'being' disrupts the body's energy flow and hinders growth
2:55:29
Resistance is not an obstacle but the source of energy for growth.
2:56:15
Excess energy intake increases cellular resistance, leading to mitochondrial dysfunction and aging
3:01:02
Being hungry occasionally triggers mitochondrial fusion and cleanup.
3:10:25
Patterned magnetic fields may deliver information that alters mitochondrial respiration.
3:12:16
Dr. Martin Picard clarifies mitochondrial energy dynamics and shares novel insights on aging and cellular function

Chapters

Martin Picard
00:00
What is Energy?, Energy Flow & Transformation
03:50
Energy, Vitality, Emotions, Sensory Perception
07:53
Sponsors: Helix Sleep & Lingo
14:18
“Mito-Centric” View of World, Mitochondrial Energy & Information Patterns
17:19
Organelles, Mitochondria & Energy Transformation; Maternal Genes
25:26
Mitotypes & Differentiation, Mitochondria as “Social Organisms”
31:12
Food & Dysfunctional Energy Transformation
36:52
Lifestyle Choices & Interests, Physiological Growth
40:02
Pregnancy, Amenorrhea; Illness & Tiredness
46:39
Sponsor: AG1
51:07
Energy Transformation & Distribution; Body’s Wisdom, Feeling Sick
52:29
Tool: Feel Your Energy; Breath & Energy
56:27
Flow of Energy; Trade-Offs, Life Purpose & Enjoyment
1:02:31
Biology, Meaningful Experiences & Energy Flow
1:10:15
Sponsor: Function
1:16:27
Inflammation, Energetic Flow
1:18:15
Child Prodigies, Species Lifespan & Mitochondrial Metabolism; Aging
1:20:43
Lifestyle & Aging: Exercise, Fasting; Inflammation, Sleep, Stimulants
1:28:56
Energetic Stress Signals, GDF-15, Cancer, Heart Failure
1:37:06
Genes, Lifestyle & Aging
1:42:18
Gray Hair Reversal, Stress; Inflammation & Aging
1:47:54
Energy Recovery, Sleep & Mitochondrial Function, Stress, Meditation
1:57:37
Tools: Yoga Nidra, NSDR; Pre-Sleep Relaxation, Energy & Restorative Sleep
2:05:16
Diet & Individualization, Clinical Trials; Mitochondria & Nutrition, Keto
2:10:58
Alcohol & Energy Budget; Stress
2:20:14
Exercise, Increase Mitochondria, Overtraining; Resistance & Growth
2:25:02
Sponsor: Waking Up
2:33:06
Supplements & Mitochondria Health, Deficiencies, SS31, Methylene Blue
2:34:41
Energy Flow & Experiences, Balance
2:41:31
Transform Through Resistance, Energetic Awareness, Connection
2:49:13
Food Overconsumption & Mitochondria Disruption; Tissues & Mitochondria
2:56:05
Mitochondrial Health Test; Tool: Ways to Increase Energy; Meditation
3:01:02
Peptides; Fertility Supplements, Urolithin A; Electromagnetic Fields
3:06:10
Acknowledgements
3:12:16
Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter
3:14:15

Transcript

Speaker 3: What's the deal? Andrew Huberman: Can people reverse the graying of their hair by reducing their stress? Can people accelerate the graying of their hair by stressing more? Dr. Martin Picard: Likely, both are true, yes. Okay. And I think what w...