The immune system relies on three layers of defense: physical barriers, innate immunity, and adaptive immunity, with antibodies like IgM and IgG marking infection stages. Nasal breathing, avoiding eye contact after exposure, and consuming fermented foods support microbiome health and mucus integrity, strengthening frontline defenses. During illness, 'sickness behavior'—driven by the vagus nerve and hypothalamus—promotes rest, fever, and photophobia to prioritize healing. Sleep enhances recovery via the glymphatic system, especially when feet are elevated. Stress reduction is critical, as cyclic hyperventilation can trigger epinephrine release, reducing inflammatory cytokines. A positive mindset activates dopamine pathways that suppress inflammation, mirroring effects seen in electroacupuncture, which engages fascial neurons to drive anti-inflammatory catecholamine release. For symptom relief, spirulina offers a natural alternative to decongestants, improving nasal function without disrupting sleep or hydration. Together, these strategies highlight the powerful role of the nervous system in modulating immunity through accessible, non-pharmacological tools.