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#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

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#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

The Tim Ferriss Show

Dec 03
The Tim Ferriss Show

The Tim Ferriss Show

Dec 03
OverviewShownoteHighlightsTranscriptChaptersPins

Shownote

Welcome to another wide-ranging "Random Show" episode that I recorded with my close friend Kevin Rose (digg.com)! This episode is brought to you by: Qlosi prescription eye drop used to treat age-related blurry near vision (presbyopia) in adults: https://...

Highlights

In this wide-ranging conversation, Tim Ferriss and Kevin Rose dive into personal growth, cutting-edge science, and the evolving landscape of technology and relationships. The discussion moves fluidly from mental health innovations to the future of AI, offering candid reflections and forward-thinking insights.
00:57
Abstinence could be a trap, according to insights from 'Awareness' by Anthony de Mello.
07:16
Five days of accelerated TMS eliminated generalized anxiety for months
21:14
D-serine plus stimulation shows promising signals in patient cohorts
29:59
Josh Waitzkin can 'feel' chess moves and once sensed a cheat during simultaneous games
33:12
Reducing beta amyloid and tau buildup through quality sleep may delay Alzheimer’s progression.
46:22
Engineers who dismissed AI for coding three months ago now find it vastly improved.
55:50
At current valuations, the guest wouldn't invest in the top AI companies.
58:05
CEOs forcing engineers to use AI daily are the ones to watch for AI transformation
1:16:59
The Tank M3 push sled is effective for strength training and back pain relief on any surface
1:24:11
Use NotebookLM to create instant podcast primers on any topic
1:30:03
An investment can still be a win if you gain skills and relationships, even when the company fails.
1:32:12
Modern dating apps are designed to be addictive and undermine relationship commitment through recurring revenue models.
1:38:18
Objective reality has no place in relationship arguments—subjective stories matter more.
1:47:19
Rapamycin resulted in a 20% boost in lifespan for Toaster.
1:50:48
Qlosi is an FDA-approved eyedrop for presbyopia with fast-acting results and mild side effects.

Chapters

Start.
00:00
Why Kevin concluded nearly seven months of sobriety, and the 2-2-2 Rule he now follows for alcohol consumption.
00:52
My recent adventures in accelerated TMS and bioelectric medicine.
07:12
The tragic death of Nolan Williams and funding future research through the Saisei Foundation.
21:09
Aphantasia vs. hyperphantasia, and Joshua Waitzkin's ability to "feel" chess.
24:23
DORAs for sleep and Alzheimer's prevention: Matt Walker, Belsomra, and the terrifying p-tau blood test.
33:12
Dale Bredesen's kitchen-sink approach to dementia and the ketogenic connection.
41:21
The rapid pace of AI development: Why your opinion from three months ago is already obsolete.
46:22
Google's full-stack advantage: TPUs, Gemini 3, and why they were built for this moment.
49:40
The future of venture capital: Seed rounds shift later as entrepreneurs gain leverage.
52:50
Kevin's three AI investment buckets: Power, data centers, and bloated companies ripe for automation.
58:05
Holiday gift ideas and recommended reading.
1:02:05
The Way App and meditation with Zen master Henry Shukman.
1:17:41
Kevin's AI stack: Nothing earbuds, Sandbar ring, Notion AI, and the NotebookLM podcast hack.
1:21:44
Oboe.fyi: The AI learning platform and my investment philosophy.
1:26:58
My new girlfriend, the perils of modern dating apps, and building a communication toolkit.
1:32:09
Terry Real's relationship wisdom: Why objective reality has no place in an argument.
1:38:17
Dog updates: Molly, a new puppy, and Toaster on rapamycin.
1:47:18
Parting thoughts and happy holidays.
1:47:58

Transcript

Kevin Rose: Kevin, Kevin. Good to see you. Tim Ferriss: Tim, Tim. Another episode of The Random Show. Glad to be back. Kevin Rose: Another episode of The Random Show. You look very dashing for people who can't see you. You have sort of hair slicked back,...